Do not start, stop, or change the dosage of any medicines without your doctor's approval. Do not use other vaginal products during treatment with this medication unless otherwise directed by your doctor.
Doing so may affect how well the drug is absorbed by your body. This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call Otherwise, call a poison control center right away.
US residents can call their local poison control center at Canada residents can call a provincial poison control center. If you miss a dose, use it as soon as you remember. However, do not use more doses in a day than prescribed. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up. Store at room temperature at 77 degrees F 25 degrees C. Brief storage between degrees F degrees C is permitted. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. Selected from data included with permission and copyright by First DataBank, Inc. This copyrighted material has been downloaded from a licensed ata provider and is not for distribution, except as may be authorized by the applicable terms of use.
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Top of the page. Uses This medication contains a female hormone called progesterone. Thus a 90 mg one time daily insertion may be equal to to mg compounded vaginal suppositories. To do so I did a Medline search from until November, and including searches of 10 journals dealing with reproductive endocrinology and infertility.
Furthermore to include the latest information I included presentations from the American Society for Reproductive Medicine meeting which I attended. The best test for efficacy of a progesterone preparation is to evaluate it under conditions where progesterone is critically required for the achievement of a pregnancy. One such circumstance is to prepare the endometrium for embryo transfer in women with absent or non-functioning ovaries using donor oocytes. The comparable ongoing pregnancy rates were Only the Khan et al 23 and Mitwally et al 39 studies provided miscarriage rates.
There was no significant difference in ongoing pregnancy rates with IM progesterone It is superior to oral progesterone tablets in that it is more effective at the endometrial level with less side effects. It does not appear to be more effective than IM progesterone despite attaining a higher endometrial concentration in the endometrium. However it provides a lot fewer side effects.
The progesterone ring may prove to be the best tolerated of all progesterone preparations and preliminary data suggest equal efficacy. The intent of this manuscript was not to provide proof that progesterone therapy improves the chances of a live birth following IVF-ET or in other circumstances, eg, women with infertility, those requiring follicle stimulating drugs or those with a history of previous miscarriage. This author is one of the physicians who touts the benefits of progesterone.
National Center for Biotechnology Information , U. Ther Clin Risk Manag. Published online Jun 4. Jerome H Check. Author information Copyright and License information Disclaimer. This article has been cited by other articles in PMC. Abstract Supplementation of progesterone in the luteal phase and continuance of progesterone therapy during the first trimester has been found in several studies to have benefits in promoting fertility, preventing miscarriages and even preventing pre-term labor.
Keywords: progesterone vaginal tablets, luteal phase, miscarriage, pregnancy rates. The importance of progesterone for health and fertility Normal ovulating women secrete progesterone during the second half of the menstrual cycle by the corpus luteum which forms from the dominant follicle from which the oocyte has been released.
Assisted reproductive technology and progesterone supplementation The one area of assisted reproductive technology where there is no question about the need for supplemental progesterone is in women with ovarian failure who become donor oocyte recipients. Various routes of administering natural progesterone One way of administering progesterone is by intramuscular IM injection.
Open in a separate window. Footnotes Disclosures The author declares no conflicts of interest. References 1. Am J Reprod Immunol. Progesterone induced blocking factor seen in pregnancy lymphocytes soon after implantation.
Evidence that the expression of progesterone-induced blocking factor by maternal T-lymphocytes is positively correlated with conception. Jones GS, Poumand K. An evaluation of etiologic factors and therapy in private patients with primary infertility.
Fertil Steril. The diagnosis and therapy of luteal phase deficiency. Ovulation-inducing drugs versus progesterone therapy for infertility in patients with luteal phase defects. Int J Fertil. The efficacy of progesterone in achieving successful pregnancy: II, in women with pure luteal phase defects. Check JH. Progesterone therapy versus follicle maturing drugs — possible opposite effects on embryo implantation. Clin Exp Obst Gyn. The efficacy of progesterone in achieving successful pregnancy: I.
Prophylactic use during luteal phase in anovulatory women. Progesterone therapy to decrease first-trimester spontaneous abortions in previous aborters. Talk with your doctor if you have concerns about any vaginal discharge.
Store progesterone vaginal inserts or gel at room temperature away from moisture, heat, and light. Progesterone vaginal suppositories should be stored in a refrigerator. Follow the instructions provided with your medicine. Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose. An overdose of progesterone vaginal is not expected to be dangerous.
Seek emergency medical attention or call the Poison Help line at if anyone has accidentally swallowed the medication. Do not use another vaginal medicine within 6 hours before or after using progesterone vaginal gel. Use only vaginal products that your doctor has recommended. This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Other drugs may interact with progesterone vaginal, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc.
Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy.
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